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miRNAs in non-alcoholic fatty liver disease

Zhen He,Cheng Hu,Weiping Jia

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 389-396 doi: 10.1007/s11684-016-0468-5

Abstract:

Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver cirrhosis and hepatocellular carcinomagene expression, and the dysregulation of miRNAs is involved in various biological processes in the livermiRNAs and NAFLD progression and have shown that circulating miRNAs reflect histological changes in the liver

Keywords： nonalcoholic fatty liver disease     nonalcoholic steatohepatitis     hepatocellular carcinoma     miRNA    

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Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholicfatty liver disease: a translational approach

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 745-759 doi: 10.1007/s11684-021-0880-3

Abstract: Decoction (LGZG) has been investigated in basic studies, with satisfactory effects on insulin resistance in non-alcoholicfatty liver disease (NAFLD).

Keywords： insulin resistance     non-alcoholic fatty liver disease     Chinese herbal medicine     randomized controlled    

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Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological

Hui Dong, Fu’er Lu, Nan Wang, Xin Zou, Jingjing Rao

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 288-293 doi: 10.1007/s11684-011-0127-9

Abstract: Haemorheological abnormalities have been described in diabetes mellitus, as well as in non-alcoholicfatty liver disease (NAFLD).However, the relationship between the changes in liver fat content and haemorheology is unknown.IHLC was quantified using proton magnetic resonance spectroscopy ( H-MRS) scanning of the liver.In summary, haemorheological disorders are linked to non-alcoholic fatty liver in type 2 diabetes.

Keywords： diabetes mellitus     type 2     haemorheology     non-alcoholic fatty liver disease    

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Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota

Ruiting Han, Junli Ma, Houkai Li

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 645-657 doi: 10.1007/s11684-018-0645-9

Abstract: Non-alcoholic fatty liver disease (NAFLD) is one of the most common metabolic diseases currently in thecontext of obesity worldwide, which contains a spectrum of chronic liver diseases, including hepaticsteatosis, non-alcoholic steatohepatitis and hepatic carcinoma.addition to the classical “Two-hit” theory, NAFLD has been recognized as a typical gut microbiota-related diseasebecause of the intricate role of gut microbiota in maintaining human health and disease formation.

Keywords： gut microbiota     NAFLD     obesity     insulin resistance     bile acids     probiotic    

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γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 262-268 doi: 10.1007/s11684-017-0584-x

Abstract: γδ T cells are enriched in the liver and exhibit liver-specific features.Accumulating evidence reveals that γδ T cells play important roles in liver infection, non-alcoholicfatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regenerationWe believe that determining the properties and functions of γδ T cells in liver diseasesγδ T cell-based therapeutic regimens for liver diseases.

Keywords： γδT cells     liver infection     non-alcoholic fatty liver disease     autoimmune hepatitis     liver fibrosis and cirrhosis     liver cancer     liver regeneration    

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New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 714-722 doi: 10.1007/s11684-021-0888-8

Abstract: A new definition of metabolic dysfunction-associated fatty liver disease (MAFLD) has recently been proposedWe aim to examine the associations of MAFLD, particularly its discordance from non-alcoholic fatty liverdisease (NAFLD), with the progression of elevated brachial-ankle pulse wave velocity (baPWV) and albuminuriaIn comparison with the non-MAFLD group, the multivariable adjusted odds ratio (OR) of MAFLD group forliver patients.

Keywords： metabolic dysfunction-associated fatty liver disease     non-alcoholic fatty liver disease     fibrosis score    

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An Update on the Efficacy and Functionality of Probiotics for the Treatment of Non-Alcoholic Fatty LiverDisease Article

Mingfei Yao, Lingling Qv, Yanmeng Lu, Baohong Wang, Björn Berglund, Lanjuan Li

Engineering 2021, Volume 7, Issue 5,   Pages 679-686 doi: 10.1016/j.eng.2020.01.017

Abstract:

Non-alcoholic fatty liver disease (NAFLD), which has a global prevalence of 20%–33%, has becomethe main cause of chronic liver disease.The mechanisms by which probiotics directly or indirectly affect the disease are illustrated, based on

Keywords： Non-alcoholic fatty liver disease (NAFLD)     Gut microbiota     Probiotics     Next-generation probiotics (NGPs    

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NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 249-261 doi: 10.1007/s11684-018-0622-3

Abstract: innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the livernatural killer T cells and their roles in hepatitis B virus and hepatitis C virus infection, autoimmune liverdiseases, alcoholic liver disease, nonalcoholic fatty liver disease, and hepatocellular carcinoma.and indicate the dynamic alteration in the role of natural killer T cells during the progression of liver

Keywords： natural killer T cells     hepatitis B virus and hepatitis C virus infection     autoimmune liver diseases     alcoholicliver disease     nonalcoholic fatty liver disease     hepatocellular carcinoma    

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Molecular mechanisms of fatty liver in obesity

Lixia Gan,Wei Xiang,Bin Xie,Liqing Yu

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 275-287 doi: 10.1007/s11684-015-0410-2

Abstract:

Nonalcoholic fatty liver disease (NAFLD) covers a spectrum of liver disorders ranging from simplesteatosis, which is characterized by excessive accumulation of triglyceride-rich lipid droplets in the liverAccumulating evidence supports that dysregulation of adipose lipolysis and liver de novo&

Keywords： nonalcoholic fatty liver disease     insulin resistance     obesity    

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Pien Tze Huang Protects Against Non-Alcoholic Steatohepatitis by Modulating the Gut Microbiota and Metabolites

Xianyi Zeng,Xiang Zhang,Hao Su,Hongyan Gou,Harry Cheuk-Hay Lau,Xiaoxu Hu,Ziheng Huang,Yan Li,Jun Yu,

Engineering doi: 10.1016/j.eng.2022.10.010

Abstract: Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease without effectivediet (CD-HFD), and methionine- and choline-deficient (MCD) diet, along with significant suppression of liverdays of PTH treatment after the onset of NASH significantly ameliorated MCD diet-induced steatosis and liver

Keywords： Pien Tze Huang     Non-alcoholic steatohepatitis     Gut barrier function     Gut microbiota    

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Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 667-685 doi: 10.1007/s11684-022-0960-z

Abstract: Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome and a commoncause of liver cirrhosis and cancer.

Keywords： Akkermansia muciniphila     NAFLD     NASH     steatosis     inflammation    

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Pathological study of 130 cases of nonalcoholic fatty liver disease based on NASH-CRN system

ZHOU Guangde, ZHAO Jingmin, DING Xiaohui, PAN Deng, SUN Yanling, YANG Jianfa, ZHAO Yulai

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 413-417 doi: 10.1007/s11684-007-0081-8

Abstract: To summarize the pathological features of nonalcoholic liver disease (NAFLD) in China based on a histologicaldesigned by the Pathology Committee of NASH Clinical Research Network (NASH-CRN), the specimens of liverImmunohistochemistry staining was used to exclude non-NAFLD cases combined with clinical data.steatosis, lobular inflammation, hepatocytic ballooning and fibrosis were presented widespread in NAFLD liverThe number of megamitochondria is more frequently be found in NAFLD, while in alcoholic liver diseases
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The Gut Microbiota, Tumorigenesis, and Liver Diseases

Guishuai Lv, Ningtao Cheng, Hongyang Wang

Engineering 2017, Volume 3, Issue 1,   Pages 110-114 doi: 10.1016/J.ENG.2017.01.017

Abstract: microbiota are instrumental in determining the occurrence and progression of hepatocarcinoma, chronic liverdiseases related to alcohol, nonalcoholic fatty liver disease (NAFLD), and cirrhosis.As far as disease management is concerned, probiotics may provide a novel direction for therapeuticsHere, we provide an overview of the relationships among the gut microbiota, tumors, and liver diseases

Keywords： Gut microbiota     Dysbiosis     Tumorigenesis     Hepatocellular carcinoma     Nonalcoholic fatty liver disease    

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Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 460-471 doi: 10.1007/s11684-021-0861-6

Abstract: Both interventions reduced visceral and subcutaneous fat and improved liver steatosis and insulin resistanceThis pilot study suggested that the effects of LCD and exercise are similar in alleviating liver steatosis

Keywords： low-carbohydrate diet     obesity     nonalcoholic fatty liver disease     continuous glucose monitoring     mean    

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decoction on CD14 expression in lipopolysaccharide signal transduction pathway of alcohol-induced liverdisease in rats

Rui ZHU MD , Lin SHEN MD , Jianguo LIU MD , Weili ZHANG MM , Ling YANG MD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 363-367 doi: 10.1007/s11684-009-0064-z

Abstract: decoction on CD14 expression in the lipopolysaccharide signal transduction pathway of alcohol-induced liverdisease in rats.disease, and 25 of these 50 rats were treated with decoction simultaneously.Liver injury was evaluated by biochemical examination.decoction pretreatment significantly protected against acute alcohol-induced liver injury, which was

Keywords： liver disease     alcohol     Zhihuang decoction     CD14     signal transduction    

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Title Author Date Type Operation

miRNAs in non-alcoholic fatty liver disease

Zhen He,Cheng Hu,Weiping Jia

Journal Article

Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholicfatty liver disease: a translational approach

Journal Article

Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological

Hui Dong, Fu’er Lu, Nan Wang, Xin Zou, Jingjing Rao

Journal Article

Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota

Ruiting Han, Junli Ma, Houkai Li

Journal Article

γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Journal Article

New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse

Journal Article

An Update on the Efficacy and Functionality of Probiotics for the Treatment of Non-Alcoholic Fatty LiverDisease

Mingfei Yao, Lingling Qv, Yanmeng Lu, Baohong Wang, Björn Berglund, Lanjuan Li

Journal Article

NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Journal Article

Molecular mechanisms of fatty liver in obesity

Lixia Gan,Wei Xiang,Bin Xie,Liqing Yu

Journal Article

Pien Tze Huang Protects Against Non-Alcoholic Steatohepatitis by Modulating the Gut Microbiota and Metabolites

Xianyi Zeng,Xiang Zhang,Hao Su,Hongyan Gou,Harry Cheuk-Hay Lau,Xiaoxu Hu,Ziheng Huang,Yan Li,Jun Yu,

Journal Article

Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge

Journal Article

Pathological study of 130 cases of nonalcoholic fatty liver disease based on NASH-CRN system

ZHOU Guangde, ZHAO Jingmin, DING Xiaohui, PAN Deng, SUN Yanling, YANG Jianfa, ZHAO Yulai

Journal Article

The Gut Microbiota, Tumorigenesis, and Liver Diseases

Guishuai Lv, Ningtao Cheng, Hongyang Wang

Journal Article

Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial

Journal Article

decoction on CD14 expression in lipopolysaccharide signal transduction pathway of alcohol-induced liverdisease in rats

Rui ZHU MD , Lin SHEN MD , Jianguo LIU MD , Weili ZHANG MM , Ling YANG MD ,

Journal Article